BIO 482L/582L

Recombinant DNA Lab

Course Syllabus

Dr. Gary Stuart 

Rm S233, x-7898 

gstuart@indstate.edu 

http://mama.indstate.edu/users/stuart

Link to On-line Course Materials:
 - BIO482/582L

I. Construct Design

Jan. 14    - Project Overview/Development
Jan. 21    - Sequence Editing and Design

II. Vector Isolation

Jan. 28    - 1.1 Restriction Digest
Feb.  4    - 1.2 Preparative Agarose Gels
Feb. 11*   - 1.3 Spin Column DNA Purification
Feb. 18    - 1.4 Fluorometric DNA Measurement

III. PCR Construction of Inserts

Feb. 25,4  - 2.1 Isolation of Genomic DNA
Mar.  4    - 2.2 PCR Amplification
Mar. 11    - Spring Break, no lab
Mar. 19    - 2.3 PCR Fragment Recovery
Mar. 25    - 2.4 Fragment Digest

IV. Ligation and Transformation

Apr.  1*   - 3.1 PCR Fragment/Vector Ligation
Apr.  8    - 3.2 Transformation & Plating
Apr. 15    - 3.3 Plasmid Minipreps (Th,F)
Apr. 22    - 3.4 Restriction Analysis
Apr. 29    - 3.5 Analytical Agarose Gels
May.  4*   - Notebooks Due for Final Examination

   * Notebooks/Assignments Due

Texts

Required: none -- lab protocols provided

 

Accessory:  Short Protocols in Molecular 

Biology (Ausubel et al., 3th edition)

Evaluations

Lab Notebooks: 2 x 100 pts  = ~200pts 

  • 1 "design" evaluation
  • 2 "experiments"
  • required format 

Sequence Analysis: 1 x 50 pts  = ~50pts 

  • Construct Virtual Plasmid