Transfer RNAs (tRNAs)

• tRNAs & rRNAs have long half-life in cell (days)

• rRNAs, tRNAs have complex secondary & tertiary structures

• RNAs fold into complex 3D shapes

• RNAs carry out a diverse array of functions

• double stranded & double helical stems &

• single-stranded regions (loops)

• often contain nonstandard mismatched base pairs

• often contain modified nitrogenous bases

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