Cells, signal transduction & gene expression, cell proliferation &
differentiation, development, cancer; Internet/teaching with
technology; science policy; science education; bioethics
Dr. Prentice's research
control of cell growth, differentiation, development, and cancer. One
major area of study involves research on adult stem cells and the signals
involved in their transformation into different cell and tissue types.
Another area of interest is the protein stathmin (also called Op18) and
related proteins, changes in stathmin in response to growth factors,
identification of stathmin-binding proteins, and the range of stathmin occurrence in the
animal and plant kingdoms.
Dr. Prentice is an
internationally recognized expert on stem
cell research, a Founding Member of Do No
Harm: The Coalition of Americans for Research Ethics, a
Fellow of the
Council for Biotechnology Policy, Wilberforce
Forum, and a Fellow of the
Institute on Biotechnology and the Human Future. He has testified before the U.S. Congress, U.S. National
Academy of Sciences, and numerous state and international legislatures and forums, and given numerous briefings, invited talks, and
media interviews on stem cell research, cloning, and bioethics.
He is involved in development of computer technologies
for teaching and research applications and has developed numerous web sites, including sites for teaching his courses on-line. He
is also interested in governmental Science Policy.
Adjunct Professor, Medical & Molecular Genetics, Indiana
University School of Medicine, Terre
Haute Center for Medical Education
Ad hoc Science Advisor, U.S.
Senator Sam Brownback, U.S.
Congressman Dave Weldon, and other Members of Congress, as well as various
governmental and non-governmental US and international organizations.
Stem Cells.” Appendix K in
Monitoring Stem Cell
Research: A Report of the President's Council
on Bioethics, 309-346. Washington, D.C.: Government Printing Office,
January, 2004. Pre-published online, 15 July 2003
(2004) “Adult Stem Cells”, Issues in Law & Medicine 19, number 3, 265-294,
(2004) “The Biotech Revolution: The Major Issues”, In: The Bioethics
Challenge (Charles Colson and Nigel Cameron, eds.), InterVarsity Press.
Jr., Dannelly, H.K. and Prentice, D.A. (2004) Chitinase in Insectivorous Bats.
Journal of Mammalogy 85, no. 1, 15-18
Chandra S., Kapur R., Chuzhanova N., Summey, V., Prentice, D.A., Barker J.,
Cooper D., Williams D.A. 2003. A rare complex DNA rearrangement in the murine
Steel gene results in exon duplication and a lethal phenotype.
Blood 102, 3548-3555; 15 Nov 2003. Prepublished online 24 July 2003
Featured (cover) article
2003. Science and Ethics: The Intertwined Debate on Stem Cells.
Journal of Family
and Consumer Sciences
Vol 95, Issue 4, 6-7; November
2003. “The Present and Future of Stem Cell Research: Scientific, Ethical and
Public Policy Perspectives”, In: Stem Cell Research: New Frontiers in Science
and Ethics (Nancy E. Snow, ed.), University of Notre Dame Press (ISBN
Prentice, D.A. 2003. “Ethics and Biotechnology”, In
Introduction to Biotechnology, (William J. Thieman and Michael A.
Palladino, eds.), Pearson Education/Benjamin-Cummings (ISBN: 0-8053-4825-5).
Published August 2003
King, C.S., Ko, W., Aloor, J.J., Prentice, D.A., Hughes, J.P. 2003. Stathmin
binds Hsp70 in the Nb2 lymphoma. Proceedings of the Indiana Academy of
Science 112, 1-8.
Prentice, D.A. 2002.
Stem Cells and Cloning, first edition, (Michael A. Palladino, series
ed.) Benjamin-Cummings (ISBN 0-8053-4864-6). Published July 2002
The Case Against Federal Funding of Human Embryonic Stem Cell Research. Yale
Journal of Health Policy, Law, and Ethics, Vol. II, Issue 1, pp. 201-209; Fall 2001
W., Johnson, M.T., Prentice, D.A., Hughes, J.P. 2001. Stathmin expression
in the placenta and embryonic brain. Proceedings of the Indiana Academy of
Science 110, 35-40.
2001. Brave New World of Genetic Engineering. in “Ethics and
Genetics”, National Catholic Bioethics Quarterly Vol. 1, No. 4:
Flurkey, W. H, M. Kelley, J. P.
Hughes, T. J. Mulkey, and D. A. Prentice. 1998. Identification of
stathmin-like proteins in plants. Plant Physiology and Biochemistry 36:
Prentice, D. A. 1998.
Spinning Biology's Web: Use of the World Wide Web for Course Supplements and
On-Line Courses. In: Enhancements: How Using Technology Changes What Faculty Do
(Nancy Millichap, Ed.), pp. 53-57. Indiana Higher Education Telecommunication
Prentice, D.A., King, C.S., Vasi, N.H., and Hughes, J.P. (1997) Novel method for isolation of stathmin-binding proteins.
Molecular Biology of the Cell 8, 129a.
Mulkey, T.J., Vaughan, M.A., Johnson, M.S. and Prentice, D.A. (1996) "Stathmin phosphorylation as a signal transduction event during elongation of roots of Zea mays L."
Plant Physiology 111, 68.
Hughes, J. P., W. H. Flurkey,
D. A. Prentice and M. T. Fox. 1993. Stathmin in mung bean leaves and rat brain.
Biochemical and Biophysical Research Communications 196: 589-595.
Meyer, N., D. A. Prentice, M. T.
Fox, and J. P. Hughes. 1992. Prolactin-induced proliferation of the Nb2
lymphoma is associated with protein kinase-C independent phosphorylation of
stathmin. Endocrinology 131: 1977-1984.
Fox, M. T., D. A. Prentice, and
J. P. Hughes. 1991. Increases in p11 and annexin II proteins correlate with
differentiation in the PC 12 pheochromocytoma. Biochemical and Biophysical
Research Communications 177: 1188-1193.