David A. Prentice

Professor of Life Sciences

Faculty Distinguished Service Award. 2003

Caleb Mills Distinguished Teaching Award, 2000

Educational Excellence Teaching Award, Arts & Sciences, 1998


Ph.D., University of Kansas

Joined the department in 1984

LIFS 112--Human Biology (General Education credit)
LIFS 405/505--Cellular Development
LIFS 406/406L/506/506L--Cell and Tissue Culture
LIFS 410--History of Biology (General Education credit)
LIFS 412--Pathophysiology
LIFS 461/461L/561/561L--Embryology
LIFS 491/691--Special Topics: Science and Politics
LIFS 601--Cell and Molecular Biology I
LIFS 633--Advanced Pathophysiology
LIFS 681--Medical Genetics
CHEM 633--Biochemistry for Medical Students

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  Dr. Prentice's Course Materials and Personal Page


Research Interests: Stem Cells, signal transduction & gene expression, cell proliferation & differentiation, development, cancer; Internet/teaching with technology; science policy; science education; bioethics

Dr. Prentice's research focuses on control of cell growth, differentiation, development, and cancer.  One major area of study involves research on adult stem cells and the signals involved in their transformation into different cell and tissue types.  Another area of interest is the protein stathmin (also called Op18) and related proteins, changes in stathmin in response to growth factors, identification of stathmin-binding proteins, and the range of stathmin occurrence in the animal and plant kingdoms.

Dr. Prentice is an internationally recognized expert on stem cell research, a Founding Member of Do No Harm: The Coalition of Americans for Research Ethics, a Fellow of the  Council for Biotechnology Policy, Wilberforce Forum, and a Fellow of the Institute on Biotechnology and the Human Future.  He has testified before the U.S. Congress, U.S. National Academy of Sciences, and numerous state and international legislatures and forums, and given numerous briefings, invited talks, and media interviews on stem cell research, cloning, and bioethics.

He is involved in development of computer technologies for teaching and research applications and has developed numerous web sites, including sites for teaching his courses on-line. He is also interested in governmental Science Policy.

Adjunct Professor, Medical & Molecular Genetics, Indiana University School of Medicine, Terre Haute Center for Medical Education

Ad hoc Science Advisor, U.S. Senator Sam Brownback, U.S. Congressman Dave Weldon, and other Members of Congress, as well as various  governmental and non-governmental US and international organizations.

Selected Publications

Prentice, D. (2003/2004) “Adult Stem Cells.” Appendix K in Monitoring Stem Cell Research: A Report of the President's Council on Bioethics, 309-346. Washington, D.C.: Government Printing Office, January, 2004. Pre-published online, 15 July 2003

Prentice D.A. (2004) “Adult Stem Cells”, Issues in Law & Medicine 19, number 3, 265-294, Spring 2004

Prentice, D.A. (2004) “The Biotech Revolution: The Major Issues”, In: The Bioethics Challenge (Charles Colson and Nigel Cameron, eds.), InterVarsity Press.  In press

Whitaker, J.O., Jr., Dannelly, H.K. and Prentice, D.A. (2004) Chitinase in Insectivorous Bats.  Journal of Mammalogy 85, no. 1, 15-18

Chandra S., Kapur R., Chuzhanova N., Summey, V., Prentice, D.A., Barker J., Cooper D., Williams D.A. 2003. A rare complex DNA rearrangement in the murine Steel gene results in exon duplication and a lethal phenotype.  Blood 102, 3548-3555; 15 Nov 2003. Prepublished online 24 July 2003
Featured (cover) article

Prentice, D.A. 2003. Science and Ethics: The Intertwined Debate on Stem Cells.  Journal of Family and Consumer Sciences  Vol 95, Issue 4, 6-7; November

Prentice, D.A. 2003. “The Present and Future of Stem Cell Research: Scientific, Ethical and Public Policy Perspectives”, In: Stem Cell Research: New Frontiers in Science and Ethics (Nancy E. Snow, ed.), University of Notre Dame Press (ISBN 0-268-01778-6); 2003

Prentice, D.A. 2003. “Ethics and Biotechnology”, In Introduction to Biotechnology, (William J. Thieman and Michael A. Palladino, eds.), Pearson Education/Benjamin-Cummings (ISBN: 0-8053-4825-5). Published August 2003

King, C.S., Ko, W., Aloor, J.J., Prentice, D.A., Hughes, J.P. 2003. Stathmin binds Hsp70 in the Nb2 lymphoma. Proceedings of the Indiana Academy of Science 112, 1-8.

Prentice, D.A. 2002. Stem Cells and Cloning, first edition, (Michael A. Palladino, series ed.) Benjamin-Cummings (ISBN 0-8053-4864-6). Published July 2002

Prentice, D.A. 2001. The Case Against Federal Funding of Human Embryonic Stem Cell Research. Yale Journal of Health Policy, Law, and Ethics, Vol. II, Issue 1, pp. 201-209; Fall 2001

Ko, W., Johnson, M.T., Prentice, D.A., Hughes, J.P. 2001. Stathmin expression in the placenta and embryonic brain. Proceedings of the Indiana Academy of Science 110, 35-40.

Prentice, D.A. 2001. Brave New World of Genetic Engineering. in “Ethics and Genetics”, National Catholic Bioethics Quarterly Vol. 1, No. 4: 529-539.

Flurkey, W. H, M. Kelley, J. P. Hughes, T. J. Mulkey, and D. A. Prentice. 1998. Identification of stathmin-like proteins in plants. Plant Physiology and Biochemistry 36: 449-455.

Prentice, D. A. 1998. Spinning Biology's Web: Use of the World Wide Web for Course Supplements and On-Line Courses. In: Enhancements: How Using Technology Changes What Faculty Do (Nancy Millichap, Ed.), pp. 53-57. Indiana Higher Education Telecommunication System, Indianapolis.

Prentice, D.A., King, C.S., Vasi, N.H., and Hughes, J.P. (1997) Novel method for isolation of stathmin-binding proteins. Molecular Biology of the Cell 8, 129a.

Mulkey, T.J., Vaughan, M.A., Johnson, M.S. and Prentice, D.A. (1996) "Stathmin phosphorylation as a signal transduction event during elongation of roots of Zea mays L." Plant Physiology 111, 68.

Hughes, J. P., W. H. Flurkey, D. A. Prentice and M. T. Fox. 1993. Stathmin in mung bean leaves and rat brain. Biochemical and Biophysical Research Communications 196: 589-595.

Meyer, N., D. A. Prentice, M. T. Fox, and J. P. Hughes. 1992. Prolactin-induced proliferation of the Nb2 lymphoma is associated with protein kinase-C independent phosphorylation of stathmin. Endocrinology 131: 1977-1984.

Fox, M. T., D. A. Prentice, and J. P. Hughes. 1991. Increases in p11 and annexin II proteins correlate with differentiation in the PC 12 pheochromocytoma. Biochemical and Biophysical Research Communications 177: 1188-1193.

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